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It's not that you can't use dependency injection in any .NET application, because you can. It's just that dependency injection fits so well in the ASP.NET MVC programming model. While building up a simple example for how my new application would be architecturally designed, I found using dependency injection with Web Forms as troublesome as trying to fit a square peg into a round hole. After some modifications and adjustments, I could get it to work, but it just didn't feel like a solid fit and certainly didn't make me any more productive.