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Makes me wonder how many of those 200,000 mcafee definitions are for threats that simply don't exist anymore, like... I dunno, Melissa, or Nimda.

And yes Mr. Grant, I would turn my desktop over to an open source antivirus system, and have actually, using both clamwin on my work and personal windows systems, and clamav on my linux desktop and several of my servers, including my email server which handles on average 25,000 emails a day.
Now is clamav my ONLY antivirus measure? surely not, all your eggs in one basket and all that, Panda AV, AVG and Norton AV all have their own place among my systems, but to date not one of the commercial ones has defeated a virus that clam hasn't also defeated.

I've been more than happy with ClamAV, so much so I'm one of their frequent, although I'm not by far not highest, donators, mostly through their "I pay ClamAV, so you don't have to" magnets and shirts from cafepress.
Last year I passed out a rather fair helping of ClamAV T-shirts at Xmas.

On a side note, I do NOT use McAfee, and most likely never will, their lack of attention to detail has cost my company, and several others we operate with, a great deal of headache going on 7 seperate occassions, from automatically updated corrupt definitions, which their software at the time apparently had no error checking for, to overly generic definitions that matched against not only our own application, but a windows service and core dll, even on a clean install.
Now we have been assured, on every occasion I might add, that the problem has been fixed and these kinds of things will not occur in the future, well, half right, each issue was fixed, but something always happened in the future.
It has been over 6 years since we cut out McAfee ties, so they might have turned a new leaf, but then again I bet you still think twice about flying ValuJet / AirTran now a days even though they haven't dropped a plane into a florida swamp in a decade.